Spectrophotometric determination of Cilastazol using p-dimethylaminobenzaldehyde

R. Vijayalakshmi*, B. Lakshmi lavanya, B. V. H. L. Sudharani, P. Aruna kumari and M. D. Dhanaraju

Research Lab, GIET School of Pharmacy, NH-5 Chaitanya Nagar, Rajahmundry - 533 294 (India).

ABSTRACT:

A simple accurate and reproducible spectrophotometric method was established for the estimation of Cilastazol based on the formation of condensation product. The method is based on the formation of yellow colored chromogen, when the drug reacts with p-Dimethylaminobenzaldehyde (PDAB). The colored species has an absorption maximum at 425 nm and obeys Beer's law in the concentration range of 6-10 mg/ml.The optimum experimental parameters for the experiment has been studied. Statistical analysis of the results has been carried out revealing high accuracy and good precision.

KEYWORDS:

Cilastazol; Spectrophotometry; PDAB

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Copy the following to cite this article: Vijayalakshmi R*, lavanya B. L, Sudharani B. V. H. L, Kumari P. A, Dhanaraju M. D. Spectrophotometric determination of Cilastazol using p-dimethylaminobenzaldehyde. Orient J Chem 2009;25(4).

Copy the following to cite this URL: Vijayalakshmi R*, lavanya B. L, Sudharani B. V. H. L, Kumari P. A, Dhanaraju M. D. Spectrophotometric determination of Cilastazol using p-dimethylaminobenzaldehyde. Available from: http://www.orientjchem.org/?p=11467