Computational analysis of unfolding and folding pathways of proteins from amide proton exchange

K. Shanthi and P. S. M. Kannan    

PR Institute of Science and Technology University, (Ponnaiyah Ramajayam College) Thanjavur - 614 904 (India).

ABSTRACT:

The exchange rate of amide proton is dependent on primary sequence of amino acids, pH and temperature. A novel computational program has been developed to predict the exchange rates of amide protons in a protein and their relationship with unfolding and folding has been analyzed. The structure -function relationship of proteins can be well probed at atomic level resolution using Hydrogen deuterium exchange methods.

KEYWORDS:

Unfolding; folding; proteins; amide proton exchange; computational analysis

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Copy the following to cite this article: Shanthi K, Kannan P. S. M. Computational analysis of unfolding and folding pathways of proteins from amide proton exchange. Orient J Chem 2009;25(4).

Copy the following to cite this URL: Shanthi K, Kannan P. S. M. Computational analysis of unfolding and folding pathways of proteins from amide proton exchange. Orient J Chem 2009;25(4). Available from: http://www.orientjchem.org/?p=22721