Chloramine-T Mediated Synthesis of 1, 3, 4-Oxadiazoles

B.C. Revanasiddappa* and E.V.S. Subrahmanyam

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Science, Paneer, Deralakatee - 574 160 (India).  

ABSTRACT:

A new series of 1, 3, 4-oxadiazole (4a-4j) derivatives have been synthesized by oxidative cyclization of various INH hydrazones with chloramine – T as a powerful oxidizing agent. The INH hydrazones (3a-3j) in turn are obtained by the reaction of INH, with substituted aromatic aldehydes. The new products were characterized by special and analytical data. All the final synthesized compounds have been evaluated for their in-vitro antibacterial and antifungal activity. Some of the compound showed promising activity.

KEYWORDS:

1, 3, 4-oxadiazoles; chloramine-T; hydrazones; antibacterial and antifungal activity

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Copy the following to cite this article: Revanasiddappa B. C, Subrahmanyam E. V. S. Chloramine-T Mediated Synthesis of 1, 3, 4-Oxadiazoles. Orient J Chem 2009;25(3).

Copy the following to cite this URL: Revanasiddappa B. C, Subrahmanyam E. V. S. Chloramine-T Mediated Synthesis of 1, 3, 4-Oxadiazoles. Orient J Chem 2009;25(3). Available from: http://www.orientjchem.org/?p=23109