Synthesis and Antimicrobial Activity of Nitrazepam (7- Nitro- 1,3- Dihydro-5- Phenyl-2h-1,4- Benzodiazepine -2-One) (Drug ) Complexes of Rare Earth Metals

Neeraj Sharma

Department of Biotechnology, G.L.A. Institute of Professional Studies, Mathura (India).

ABSTRACT:

Metal complexes of Th (IV), Ce (IV) and UO2 (IV) with drug nitrazepam (NZ) (7- nitro- 1,3- dihydro-5- phenyl-2H-1,4- benzodiazepine-2-one) have been synthesized and characterized with the help of elemental analysis and IR spectral data. On the basis of IR spectral data the band in the free ligand attributed to u (C =N ) & u (N-H) undergoes the shifting to lower region in all the complexes, indicating the participation of azomethine nitrogen N (4 ) & N (1) in complexation. All the coloured complexes have been screened for their antimicrobial activity against fungi viz. A. niger, A. flavous, P. triticena, Fusarium species and bacteria viz. E. coli, B. subtilis, S. typhi, S. aureus. The results of antimicrobial activity show that Nz- metal complexes of tetravalent metals have more potency towards experimental fungi and bacteria. It also shows that Th (IV) complex is more toxic against bacteria E. coli.

KEYWORDS:

Synthesis; Antimicrobial activity; nitrazepam

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Copy the following to cite this article: Sharma N. Synthesis and Antimicrobial Activity of Nitrazepam (7- Nitro- 1,3- Dihydro-5- Phenyl-2h-1,4- Benzodiazepine -2-One) (Drug ) Complexes of Rare Earth Metals. Orient J Chem 2009;25(2).

Copy the following to cite this URL: Sharma N. Synthesis and Antimicrobial Activity of Nitrazepam (7- Nitro- 1,3- Dihydro-5- Phenyl-2h-1,4- Benzodiazepine -2-One) (Drug ) Complexes of Rare Earth Metals. Orient J Chem 2009;25(2). Available from: http://www.orientjchem.org/?p=23247