Studies on Synthesis and Antibacterial Activity of Some New 3-(2-Hydroxyphenyl)-4-Benzoyl-5-Phenylisoxazolines

Madhuri P. Bhise¹, V. M. Raut², R. P. Pawar², D. P. Gulwade² and N. A. Junghare²

¹MCT's Rajiv Gandhi Institute of Technology, Andheri (W) Mumbai (India).

²Department of Chemsitry, Government Vidarbha Institute of Science and Humanities, Amravati (India).

ABSTRACT:

3-Aroyl flavanones (1a-j) were allowed to react with NH2 OH- HCl in dioxane containing piperidine to give the corresponding 3-(2-hydroxyphenyl)-4-aroyl-5-arylisoxazolines (2a-j). There structural assignment are based on the elemental analysis, spectra data (IR, UV & NMR) and chemical properties. All these compounds were tested in vitro for their antibacterial activity by disk-diffusion method against Gram positive and Gram negative bacterials. In some of the compounds the results are found to be encouraging.

KEYWORDS:

3-(2-Hydroxyphenyl)-4-royl-5-arylixosazoline; antibacterial activity

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Copy the following to cite this article: Bhisel M. P, Raut V. M, Pawar R. P, Gulwade D. P, Junghare N. A. Studies on Synthesis and Antibacterial Activity of Some New 3-(2-Hydroxyphenyl)-4-Benzoyl-5-Phenylisoxazolines. Orient J Chem 2009;25(2).

Copy the following to cite this URL: Bhisel M. P, Raut V. M, Pawar R. P, Gulwade D. P, Junghare N. A. Studies on Synthesis and Antibacterial Activity of Some New 3-(2-Hydroxyphenyl)-4-Benzoyl-5-Phenylisoxazolines. Orient J Chem 2009;25(2). Available from: http://www.orientjchem.org/?p=23243