Synthesis of 5-(Substitutedphenyl)-{3-[4-(2-Methyl-4-(4-Hydroxy Benzylidene)-5-Oxo-Imidazol-1-Yl)]Phenyl} -Isoxazol and Study of the Antimicrobial Activities

P. S. Patel¹, R. A. Shah¹, D. K. Trivedi¹ and P. J. Vyas²

¹Department of Chemistry, Sheth L.H. Science College, Mansa - 382 845 (India).

²Department of Chemistry, Sheth M.N.. Science College, Patan - 384 265 (India).

 

ABSTRACT:

5-(substitutedphenyl)-{3-[4-(2-methyl-4-(4-hydroxy benzylidene)-5-oxo-imidazol-1-yl)]phenyl}-isoxazol have been prepared by the refluxation for ten hours of 4-(4-hydroxybenzylidene)-1-{4-[3-(stituted phenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one with hydroxylamine hydrochloride and 40% potassium hydroxide in presence of dioxane. The intermidiate 4-(4-hydroxybenzylidene)-1-{4-[3-(stituted phenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-(4-hydroxybenzylidene)-2-methyl-3,5-dihydro-imidazol-5-one with various aldehydes.

KEYWORDS:

Synthesis; substitutedChalcones; substituted isoxazolines

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Copy the following to cite this article: Patel P. S, Shah R. A, Trivedi D. K, Vyas P. J. Synthesis of 5-(Substitutedphenyl)-{3-[4-(2-Methyl-4-(4-Hydroxy Benzylidene)-5-Oxo-Imidazol-1-Yl)]Phenyl} -Isoxazol and Study of the Antimicrobial Activities. Orient J Chem 2009;25(1).

Copy the following to cite this URL: Patel P. S, Shah R. A, Trivedi D. K, Vyas P. J. Synthesis of 5-(Substitutedphenyl)-{3-[4-(2-Methyl-4-(4-Hydroxy Benzylidene)-5-Oxo-Imidazol-1-Yl)]Phenyl} -Isoxazol and Study of the Antimicrobial Activities. Orient J Chem 2009;25(1). Available from: http://www.orientjchem.org/?p=23348