Synthesis of Novel Bioactive Heterocyclic Compounds - 4 -Thiazolidinone Via Solvent - Free Microwave Mediated Technology

Wasudha Thakre¹* and Jyotsna Meshram¹

Department of Chemistry, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur - 440 033 India.

ABSTRACT:

A rapid and solvent free approach involving microwave technique by solid catalyst for synthesis of 4-(arylidene)-phenyl azo benzene 3a-j is presented in this paper. A series of 4-thiazolidinones 4a-f have been prepared by reaction of 4-(arylidene)-phenyl azo benzene 3a-f with mercaptoacetic acid. Azomethines 3a-j have been prepared by condensation of 4-amino azo benzene 1 with substituted aryl aldehydes 2a-j using conventional as well as microwave method. All products have been characterised by IR, 1H NMR and elemental analysis.

KEYWORDS:

Solvent-free synthesis; 4-thiazolidinones; azomethines; 4-amino azo benzene

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Copy the following to cite this article: Thakre W, Meshram J. Synthesis of Novel Bioactive Heterocyclic Compounds - 4 -Thiazolidinone Via Solvent - Free Microwave Mediated Technology. Orient J Chem 2008;24(3).

Copy the following to cite this URL: Thakre W, Meshram J. Synthesis of Novel Bioactive Heterocyclic Compounds - 4 -Thiazolidinone Via Solvent - Free Microwave Mediated Technology. Orient J Chem 2008;24(3). Available from: http://www.orientjchem.org/?p=25089