Synthesis of Fluoro Substituted Benzothiazoles Incorporated with 1,3,4-Thiadiazoles for Biological and Pharmacological Screening

Gangadhar Shaw, G. M. Sreenivasa and E. Jayachandran

P. G. Department of Pharmaceutical Chemistry. S.C.S. College of Pharmacy, Harapanahalli - 583 131 India.

ABSTRACT:

Various substituted 2[5'-(3-Methyl benzene)-1',3',4-thiadiazol-2'-yl amino)-6-flouro-7substituted (1,3) benzothiazoles and 2[5'-(p-chlorobenzene)-1',3',4'-thiadiazole-2'-yl amino) -6-fluoro-7substituted (1,3) benzothiazole containing different functional groups have been synthesized by condensing hydrazine hydrate with substituted 2-aminobenzothiazole in presence of ammonia, carban disulphide with ethanol and sodium chloroacetate. Further it is treated with various aromatic acid (p-chloro benzoic acid and 3-methyl benzoic acid) in presence of pyridine. The identity of compounds were confirmed on the basis of their spectral (UV, IR, 1H NMR and MASS) data. Further, they have been screened for their antimicrobial, anti-inflammatory and anticonvulsant activities.

KEYWORDS:

Fluorine; Benzothiazole; Thiadiazole; anti-microbial

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Copy the following to cite this article: Shaw G, Sreenivasa G. M, Jayachandran E. Synthesis of Fluoro Substituted Benzothiazoles Incorporated with 1,3,4-Thiadiazoles for Biological and Pharmacological Screening. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Shaw G, Sreenivasa G. M, Jayachandran E. Synthesis of Fluoro Substituted Benzothiazoles Incorporated with 1,3,4-Thiadiazoles for Biological and Pharmacological Screening. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23883