Synthesis of bioactive molecule fluoro benzothiazole comprising quinazolinyl oxadiazoles derivative for biological and pharmacological screening

Gajraj Sharma, G.M. Sreenivasa and E. Jayachandran*

P.G. Department of Pharmaceutical Chemistry. SCS College of Pharmacy, Harapanahalli-583 131 (India)

ABSTRACT:

Various substituted 3-{6-fluoro-7-(substituted)-1,3-benzothiazol-2-yl-1-[(4-acetyl-5-methyl-5- phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-2-thioxo-2,3-dihydroquinazoline-4 (1H) -one and 3-{(6- fluoro –7- (substituted) - 1,3 -benzothiazol-2-yl-1-({4-acetyl-5-[4-(dimethylamino)phenyl]-4,5-dihydro- 1,3,4-oxadiazol-2-yl}methyl) -2- thioxo -2,3- dihydroquinazolin –4 (1H)-one. containing different functional groups have been synthesized by condensing anthranilic acids with substituted 2-aminobenzothiazoles in dry pyridine and then by condensing with ethylchloroacetate in presence dry acetone and K2CO3. The identity of compounds were confirmed on the basis of their spectral (UV, IR, 1 H NMR and MASS) data. Further, they have been screened for their antimicrobial activities.

KEYWORDS:

Fluorine; benzothiazole; quinazoline (Cyclo addition reaction) Oxadizole (Schiff base)

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Copy the following to cite this article: Sharma G, Sreenivasa G. M, Jayachandran E. Synthesis of bioactive molecule fluoro benzothiazole comprising quinazolinyl oxadiazoles derivative for biological and pharmacological screening. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Sharma G, Sreenivasa G. M, Jayachandran E. Synthesis of bioactive molecule fluoro benzothiazole comprising quinazolinyl oxadiazoles derivative for biological and pharmacological screening. Available from: http://www.orientjchem.org/?p=11285