Synthesis of Benzothiazole Derivatives and Study of Their Antifungal Activities

Sibaji Sarkar¹*, T. Y. Pasha¹, B. Shivakumar² and Rajshekar Chimkode

¹JJC Trust Sanchalit N. R. Vekaria Institute of Pharmacy and Research Center, C. L. College Campus, Junagadh - 362 001 India. ²SCS College of Pharmacy Harpanahalli - 583 001 India.

ABSTRACT:

Synthesis of new benzothiazole derivatives, derived from the condensation of 2-amino-7-chloro-6 fluro benzothiazole with different aroyl chloride and obtained compounds has been (substituted phenyl carboxamido) benothiazole and obtained compounds has been subjected to a substitution reaction with different amines to yield 7alkyl/aryl amino-6-fluro-2-phenyl carboxamido benzothiazoles and 7alkyl/aryl amino-6-fluro-2 (3-nitro phenyl carboxamido) benzothiazoles. The synthesized compounds were screened for antifungal activities.

KEYWORDS:

Benzothiazole derivatives; antifungal activity

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Copy the following to cite this article: Sarkar S, Pasha T. Y, Shivakumar B, Chimkode R. Synthesis of Benzothiazole Derivatives and Study of Their Antifungal Activities. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Sarkar S, Pasha T. Y, Shivakumar B, Chimkode R. Synthesis of Benzothiazole Derivatives and Study of Their Antifungal Activities. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=24400