Synthesis and Antimicrobial Evaluation of 8-[{4- (2-Substituted Phenyl–5-Oxo-Thiazolidin-1-Yl)- 5-Thiobutyl Triazolo} Methoxy] Quinolines

T. Chandra¹, S. K. Bhati¹, H. Panwar¹ and K. P. S. Vishnoi¹

¹Department of Pharmacology, L. L. R. M. Medical College, Meerut - 250 004 India. ²Department of Chemistry, K. G. College, Muradabad India.

ABSTRACT:

Several 8-substituted derivatives of quinoline were synthesized. The structure of the prepared compounds were characterezied by elemental and spectral (I.R.,1H-NMR, Mass) analysis. These molecules were evaluated for their efficacy as antimicrobials in vitro by disc diffusion method against some selected pathogenic strains in compare to gatifloxacin and fluconazole.

KEYWORDS:

Quinolines; antibacterial activity; antifungal activity; toxicity

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Copy the following to cite this article: Chandra T , Bhati S. K , Panwar H, Vishnoi K. P. S. Synthesis and Antimicrobial Evaluation of 8-[{4- (2-Substituted Phenyl–5-Oxo-Thiazolidin-1-Yl)- 5-Thiobutyl Triazolo} Methoxy] Quinolines. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Chandra T , Bhati S. K , Panwar H, Vishnoi K. P. S. Synthesis and Antimicrobial Evaluation of 8-[{4- (2-Substituted Phenyl–5-Oxo-Thiazolidin-1-Yl)- 5-Thiobutyl Triazolo} Methoxy] Quinolines. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23881