Novel Synthesis, Characterization and Antimicrobial Activity of Some Nitrogen Containing Heterocyclic Moiety

V. J. Kaila¹, D. J. Desai¹, K. D. Patel¹*, A. J. Maheta¹ an

¹Department of Chemistry, V. P. and R. P. T. P. Sci. College, S. P.University, V. V. Nagar India. ²Department of Microbiology, V. P. and R. P.T. P. Sci. College, S. P. University, V. V. Nagar India.

ABSTRACT:

A series of 3-[(2,4-Dinitro phenyl)-(substituted amino)-1-ylmethyl-amino]-2-substituted phenyl-5-(3,4,5-trimethoxy benzylidene)-3,5-dihydro-imidazol-4-one derivatives were synthesized by the condensation of 2-substituted phenyl-4- (3,4,5-trimethoxy benzylidene)- 4H-oxazol-5-one and 2,4-Dinitro phenyl hydrazine in Pyridine. Which was further carried out by Mannich reaction using different secondary amines to afford title compounds. The synthesized compounds have been characterized on the basis of elemental analysis and spectral studies like IR, 1H- NMR, etc. Further they were assayed for their Antimicrobial activity against E.coli, B.subtilis bacterial species and A.niger fungal microorganism.

KEYWORDS:

Oxazolone; Imidazolone; IR; 1H- NMR; C; H; and N analysis; Antimicrobial activity

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Copy the following to cite this article: Kaila V. J, Desai D. J, Patel K. D, Maheta A. J. Novel Synthesis, Characterization and Antimicrobial Activity of Some Nitrogen Containing Heterocyclic Moiety. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Kaila V. J, Desai D. J, Patel K. D, Maheta A. J. Novel Synthesis, Characterization and Antimicrobial Activity of Some Nitrogen Containing Heterocyclic Moiety. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23920