Development of New Spectrophotometric Methods for The Determination of Alfuzosin Hydrochloride in Bulk and Pharmaceutical Formulations

D. Ravi Kumar¹, S.V. M. Vardhan², D. Ramachandran³ and C. Rambabu⁴

¹Department of Chemistry, Acharya Nagarjuna University Nuzvid Campus, Nuzvid.

²Department of Biochemistry, Acharya Nagarjuna University Nuzvid Campus, Nuzvid.

ABSTRACT:

Two simple and sensitive methods A and B for the spectrophotometric determination of Alfuzosin hydrochloride have been described. These methods are based on the formation of purple color and red- violet colored chromogens obtained when the drug was diazotized with nitrous acid followed by coupling with Phloroglucinol and Resorcinol, exhibiting lmax at 520 and 600 nm respectively. These methods obey Beer’s law in the concentration ranges of 4-20 and 2-10 μg/mL. These methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations.

KEYWORDS:

Alfuzosin hydrochloride; chromogen; spectrophotometry

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Copy the following to cite this article: Kumar D. R, Vardhan S. V. M, Ramachandran D, Rambabu C. Development of New Spectrophotometric Methods for The Determination of Alfuzosin Hydrochloride in Bulk and Pharmaceutical Formulations. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Kumar D. R, Vardhan S. V. M, Ramachandran D, Rambabu C. Development of New Spectrophotometric Methods for The Determination of Alfuzosin Hydrochloride in Bulk and Pharmaceutical Formulations. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=24423