Development and evaluation of matrix type transdermal patches of aspirin

Kapil kumar¹*, Neeraj sissodia¹, A. K. Rai¹ and S. K. Prajapati²

¹Vivek college of technical education, Bijnore India. ²Institute of Pharmacy, Bundelkhand University, Jhansi India.

ABSTRACT:

Objective of the present study involves development and evaluation of matrix type transdermal patches for controlled delivery of aspirin as a model drug in order to avoid it,s frequent dosing , avoidance of adverse effects and improving the bioavailability of aspirin.Transdermal patches were prepared by using different polymers i.e. Eudragit RS 100, chitosan ,polyethylene glycol 4000 and polyvinylpyrrolidone K30. Transdermal patches were evaluated in terms of physical properties and in-vitro release studies by using phosphate buffer of pH 5.0 and in-vitro skinpermeation studies was performed by using rat skin and phosphate buffer of pH 7.4 for 11 hrs. The effect of penetration enhancer (20 % propylene glycol) was estimated on the in-vitro skin permeation profile of the patches.

KEYWORDS:

Matrix type transdermal patches; Aspirin; model drug

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Copy the following to cite this article: kumar K, Sissodia N, Rai A. k, Prajapati S. K.Development and evaluation of matrix type transdermal patches of aspirin. Orient J Chem 2008;24(2).

Copy the following to cite this URL: kumar K, Sissodia N, Rai A. k, Prajapati S. K.Development and evaluation of matrix type transdermal patches of aspirin. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23887