2-((4-Oxo-2-Thiazolidin-5-Ylidine) Methyl) Phenoxy) Acetamides as Anticonvulsant Agents

Jagbir Gagoria¹, Anurag Khatkar, Sarita Khatkar, Rekha Rao², Kuldeep Singh³ and Arun Nanda⁴

¹R. K. S. D College of Pharmacy, Kaithal - 136027 India. ²Institute of Pharmacy, M. M. University, Mullana, Ambala India. ³Institute of Pharmacy, Integral University, Lucknow India. ⁴Faculty of Pharmaceutical Sciences, M. D.University, Rohtak India.

ABSTRACT:

A new series of (Z)-N-(substitutedphenyl)-2-(2-((4-oxo-2-thiazolidin-5-ylidine) methyl)phenoxy)acetamides (d1- 8) have been synthesized by reaction of 2-thioxo-4-thiazolidinone(a) with salicyldehyde and vanilline, which upon O-alkylation with different chloro - acetamides (c1- 4) form the final derivatives (d1- 8). The physical and spectral data of synthesized compounds are determined. The synthesized compounds have been screened for their anti-convulsant activity by MES method.

KEYWORDS:

Acetamides; Anti-convulsant activity; MES method

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Copy the following to cite this article: Gagoria J, Khatkar A, Khatkar S, Rao R, Singh K, Nanda A. 2-((4-Oxo-2-Thiazolidin-5-Ylidine) Methyl) Phenoxy) Acetamides as Anticonvulsant Agents. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Gagoria J, Khatkar A, Khatkar S, Rao R, Singh K, Nanda A. 2-((4-Oxo-2-Thiazolidin-5-Ylidine) Methyl) Phenoxy) Acetamides as Anticonvulsant Agents. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=24382/a>.