Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines
Y. Rajendra Prasad*, P. Praveen Kumar and P. Ravi Kumar
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003 (India)
A variety of 2-amino-4-(substituted phenyl/anthryl)-6-(2'-pyridyl) pyrimidines (2A-F) were synthesized by reacting 1-(2'-pyridyl)-3- (substituted phenyl/anthryl)-2-propene-1-ones (1A-F) with guanidine hydrochloride. The required 1-(2'-pyridyl)-3- (substituted phenyl/anthryl)-2-propene-1-ones (1A-F) were prepared by the condensation of 2-acetyl pyridine with different aldehydes according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR, 1H NMR spectroscopic data and microanalyses. The synthesized pyrimidine derivatives were screened for their antimicrobial activity and some of the compounds showed significant activity.
KEYWORDS:Pyrimidines; chalcones; synthesis; antimicrobial activity
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| Copy the following to cite this article: Prasad Y. R, Kumar P. P, Kumar P. R. Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines. Orient J Chem 2007;23(3). |
| Copy the following to cite this URL: Prasad Y. R, Kumar P. P, Kumar P. R. Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines. Orient J Chem 2007;23(3). Available from: http://www.orientjchem.org/?p=20525 |
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