ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Trisubstituted Thiadiazoles as Bio-Active Agents

Ashok Kumar1*, Sudhir KumarBhati1,Chatrasal Singh Rajput1 and Jai Singh2

1Department of Pharmacology L.L.R.M. Medical College, Meerut (India) 2Department of Chemistry D.N. College Meerut - 250 002 (India)  

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ABSTRACT:

5-substitutedbenzylideneamino-1,3,4,- thiadiazole-2-thiols (1a-1c), 5-substituted- benzylideneamino-2- thiocarbethoxy- methyl-1,3,4-thiadiazoles (2a-2c), 5- substituted- benzylideneamino-2-(thiosemicarbazidomethyl -thio)- 1,3,4-thidiazoles (3a-3c), 5- substitutedbenzylideneaminno-2-[5'-amino-1',3',4'-thiadiazole-2'-ylthiomethyl]-1,3,4-thiadiazoles ( 4a-4c), 5-substitutedbenzylidene amino-2-[5'-(substituted benzylideneamino-1',3',4'- thiadiazol-2'-yl)-thiomethyl]-1,3,4- thiadiazoles (5a-5l), 5-[4'-oxo-3'-chloro-2'-substitutedphenyl-azetidin-1'-yl]-2-[{5-(4'’’-oxo-3'’’ chloro-2'’’- arylazetidin-1'’’-yl)-1"",3"",4""-thiadiazol -2""-yl}-thiomethyl]-1,3,4-thiadiazoles (6a-6l), have been synthesized in present study. The structures of these newly synthesized compounds are confirmed by their analytical and spectral data. These compounds were also evaluated for their anti-inflammatory, ulcerogenic and analgesic activities. The compound 6J have shown most active anti-inflammatory and analgesic activity with better ulcerogenic activity than phenylbutazone."

KEYWORDS:

Thiadiazoles; azetidinones; anti-inflammatory; ulcerogenic; analgesic activities; toxicity study

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Kumar A, KumarBhati S, Rajput C. S, Singh J. Trisubstituted Thiadiazoles as Bio-Active Agents. Orient J Chem 2007;23(1).


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Kumar A, KumarBhati S, Rajput C. S, Singh J. Trisubstituted Thiadiazoles as Bio-Active Agents. Orient J Chem 2007;23(1). Available from: http://www.orientjchem.org/?p=19731



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