ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis and Anti-Tumor Activity of Some Benzothiazole and Benzimidazole Selenolato Metallic Complexes

Volume 22, Number 2

Meenakshi Gupta, A. K. Das* and Mayukh Baidya

Krupanidhi College of Pharmacy, Sarjapur Road, Koramangala, Bangalore - 560 034 (India)

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ABSTRACT:

Various benzothiazole and benzimidazole selenolato metallic complexes, M [Se (BTZ)] 2 and M [Se (BMZ)] 2, were synthesized by the reaction of MCl2 (where M = Zn (II), Hg (II), Cd (II), Cu (II), Ni (II) on selenolato ligands, BTZ Se+Li- and BMZ Se+Li- respectively (where BTZ = benzothiazole, BMZ = benzimidazole). The compounds synthesized were characterized by various spectral analysis and screened for anti-tumour activity using Erhlich Ascites Carcinoma (EAC) Cell induced albino mice. Various parameters were noted to confirm the efficiency of the derivatives as anti-tumor agent. The compounds, Ia and IIa were found to be significantly potent while Ib, Ic, IIb, IIc and IIe were moderate anti-tumour.

KEYWORDS:

Benzothiazole; benzimidazole; selenolato ligand; Erhlich Ascites Carcinoma (EAC); anti-tumor activity

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Gupta M, Das A. K, Baidya M. Synthesis and Anti-Tumor Activity of Some Benzothiazole and Benzimidazole Selenolato Metallic Complexes. Orient J Chem 2006;22(2).

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Gupta M, Das A. K, Baidya M. Synthesis and Anti-Tumor Activity of Some Benzothiazole and Benzimidazole Selenolato Metallic Complexes. Orient J Chem 2006;22(2). Available from: http://www.orientjchem.org/?p=19507

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