Derivatization of Heterocyclic Scaffolds Through Solid Phase Synthesis

Madhvi Sisodia* and R. K. Agrawal

Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar - 470 003 (India)

The nucleophilic substitution reaction on acetylated derivatives of Baylis-Hillman adduct (BH) adducts of isoxazolecarboxayaldehyde and extended this synthetic strategy to simple aldehydes derivatives in excellent yields. The solution phase chemistry confirmed that phenols undergo SN2’–SN2’ reaction, the reaction was optimize on solid support and characterize the products. These synthetic strategies can be extended towards the generation of chemical library of the heterocyclic scaffold (such as isoxazole).

Baylis-Hillman (BH); isoxazolecarboxayaldehyde; phenol