Synthesis and Biological Evaluation of the 1-[4’-Imino (Substituted Phenyl) Phenyl]-2-Phenyl-4-(4-N:N-Dimethyl Amino Benzylidene)-Imidazol-5-One"

D. K. Trivedi and K. R. Desai¹

¹Department of Chemistry, Sheth L. H. Science College, Mansa - 382 845 (India) ²Department of Chemistry, South Gujarat University, Surat - 350 007 (India)

The anti microbial activities of 1-[4’-imino(substituted phenyl)]-2-phenyl-4-(4-N:N-dimethyl amino benzylidene)-imidazol-5-one have been evaluated by using cup-borer method against gram-negetive bacteria Escherichia coli, gram-positive bacteria Staphylococcus aureus and fungus Candida albicans using their DMF solution. The activities were compared with penicillin, Kanamycin, Baycor-25w.p., and Amphotericin. The above compounds were prepared by condensing 1-[4’-imino (substituted phenyl)]-2-phenyl-4-(4""-N:N-dimethyl amino benzylidene)-imidazol-5-one and different aromatic aldehydes using absolute alcohol as a solvent."

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