Inhibition of Albumin Denaturation and Anti-Inflammatory Activity of Substituted Pyrimidinoimidazolinones

Sameh Ayadi, Khaled Essalah* and Manef Abderrabba

Unite de recherche Physico-Chimie Molecularie, IPEST Boite Postale- 512070, Marsa, Tunisie

In order to prepare a title compounds, impressed by the wide range of biological activity of various substituted pyrimidine by imidazolinones. A very few biheterocycle containing pyrimidine with imidazolines as the heterocyclic partners. 1. Ethyl cyanoacetate on condensation with thiourea in the presence of diverse aromatic aldehyde to give in appreciable yield. 2. Thus (1) compound is subjected to methylation by methyliodide to give the N-methyl substituted at N-3, and mercapto form methylthio group at C2 in II compound1. 3. In order to get the hydrazine group in the pyrimidine ring the II compound is substituted to hydrazinohydrates to eliminate methylthio group to form III1. 4. Synthesis of substituted oxazolones by Erlenmeyer condensation. These compounds are used as intermediates for synthesis of imidazolinone ring2. 5. Hydrazino substituted pyrimidines are treated with different substituted oxazolones to get expected biodynamic leads.

Oxazolones; Imidazolinone; Pyrozolo-pyrimidines