Thaidiazole Substituted 1h-Isoindole-1,3-2(H)-Diones  as Biologically Active Agents

Rinku Sinha, S. P. Garg and Pramilla Sah*

Department of Chemistry, J.N.V. University, Jodhpur -342005, (India)

2-[5-(2-aryl/aryl substituted amino-1,3,4-thiadiazolo)-thio carbo-methyl/ethyl]-1’ H-lsoindo-1',3'-(2H)-Diones (IVa-IVf) and 2'-(5-alkyl-1,3,4-thiadiazolo)-craboxamido-methyl/ethyl]-1'-Isoindole-1',3'-(2H)-Diones(Va-Vd) were synthesized by fusing the acid chlorides of N-glycyl/alanyl phthalimides with 2-arylamino-5-mercapto-1,3,4-thiadiazoles (IIa-IIc) and 2-amino-5-alkyl substituted 1,3,4-thiadiazoles (IIIa, IIIb). These derivatives were screened for their antibacterial, antifungal and antileishmanial activities (in-vitro). Some of the thiadiazole derivatives were found to be active.

Thiadiazole; Isoindole; Antibacterial; Antifungal; Antileishmanial