Estimation of Rofecoxib in Bulk Drugs And in Dosage Forms by Rp-Hplc
D. Gowri Sankar*, K. Devi Priya, M. Vamsi Krishna and P.V.M. Latha
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530 003 (India)
A reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of Rofecoxib in bulk as well as in pharmaceutical dosage forms. The quantification was carried out using a Partisil C-18 octa decyl silane column 250mm x 4.6 mmi.d, 5μm particle size in isocratic mode, with mobile phase comprising acetonitrile and water in the ratio 60: 40(v/v). Glibenclamide was used as internal standard. The detection was carried out at 240 nm and the linearity was found to be in the range of 0.1-40 μg/ml. The proposed method was found to be simple, precise and hence can be applied for routine quality control analysis of Rofecoxib in bulk drugs and in pharmaceutical dosage forms.
KEYWORDS:RP-HPLC; Rofecoxib; Pharmaceutical dosage forms
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| Copy the following to cite this article: Sankar D. G, Priya K. D, Krishna M. V, Latha P. V. M. Estimation of Rofecoxib in Bulk Drugs And in Dosage Forms by Rp-Hplc. Orient J Chem 2016;2004;20(3). |
| Copy the following to cite this URL: Sankar D. G, Priya K. D, Krishna M. V, Latha P. V. M. Estimation of Rofecoxib in Bulk Drugs And in Dosage Forms by Rp-Hplc. Orient J Chem 2004;20(3). Available from: http://www.orientjchem.org/?p=18784 |
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