ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of 3-Substituted 6--Hydroxy-3,4-Dihydroxy-2H-1,2,4-Benzothiadiazine-1,1-Dioxide-7-Sulphonamides, Anti-Microbial Activity and Diuretic Activity

Volume 20, Number 2

Palak R. Shah, Ashutosh K. Bhatt, Kasanali Karadia and H.D. Patel

Chemistry Department, St.Xavier's College, Ahmedabad-380 009 (India)

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ABSTRACT:

3-Subsituted-6-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadizine-1, 1-dioxide-7-5-sulphonamides were prepared. Starting from 3-amino phenol and chloro sulphonic acid, Addition of ammonia give 3-amino phenol-4,6-disulphonamids. Addition of 3-aino phenol-4,6 disulphonamide in different aldehydes resulted in benzothiadiazine derivatives. The physical and spectral data of synthesized compounds were determined. The synthesized compounds were screened for thier antibacterial, antifungal and diuretics activity so, there compounds may be useful as better hypotensive compounds.

KEYWORDS:

Benzothiadiazine derivatives; antimicrobial activity

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Shah P. R, Bhatt A. K, Karadia K, Patel H. D. Synthesis of 3-Substituted 6--Hydroxy-3,4-Dihydroxy-2H-1,2,4-Benzothiadiazine-1,1-Dioxide-7-Sulphonamides, Anti-Microbial Activity and Diuretic Activity. Orient J Chem 2004;20(2).

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Chitre K. P, Jaywsal K. P, Patel H. D. Synthesis and Characterization of 3-Substituted Phenyladine/Furfurylidene Amino-2h-1-Benzopyran-2-Ones and Study of Their Anti-Fungal and Anti-Bacterial Activities. Orient J Chem 2004;20(2). Available from: http://www.orientjchem.org/?p=18677

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