Synthesis and Characterization of Benzimidazole Derivatives and Study of Their Antibacterial and Antifungal Activities
Ashutosh K. Bhatt, Palak R. Shah, Hasanali Karadia and H. D. Patela
Chemistry Laboratory, Xavier Research Foundation, St. Xavier's College Campus, Ahmedabad
Reaction of 2-(2-Hydroxy phenyl) 1-H benzimidazole 1 with p-aminobenzoic acid and aromatic aldehydes in ethanol furnishes 1-(μ-p-carboxyphenyl-aminobenzyl) 2-(2-hydroxy phenyl) benzimidazole 2. Which on treatment with o-phenylene diamine in pyridine results in the formation of 1-(μ-p-benzimidazolyl-aminobenzyl) 2-(2-hydroxy phenyl) benzimidazole 3 in the varying from 60-65%. Antibacterial and antifungal activities of 3 were reported.
KEYWORDS:Benzimidazole derivatives; antimicrobial activity
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| Copy the following to cite this article: Bhatt A. K, Shah P. R, Karadia H, Patel H. D. Synthesis and Characterization of Benzimidazole Derivatives and Study of Their Antibacterial and Antifungal Activities. Orient J Chem 2001;20(2). |
| Copy the following to cite this URL: Bhatt A. K, Shah P. R, Karadia H, Patel H. D. Synthesis and Characterization of Benzimidazole Derivatives and Study of Their Antibacterial and Antifungal Activities. Orient J Chem 2001;20(2). Available from: http://www.orientjchem.org/?p=18687 |
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