ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of 2-Azetidinones as Potential Antimicrobial Agents

Volume 19, Number 2

K. V.Hirapara, A. M. Joshi, S. P. Patel and H. H. Parekh*

Department of Chemistry, Saurashtra University, Rajkot- 360 005 (India)

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ABSTRACT:

A series of new 4-aryl-3-chloro-1-(r-5-methylisoxazol-3-yl sulphonamido phenyl)-2-azetidinones (3a-l) have been synthesized by cyclisation of substituted benzal r-5-methyl isoxazol-3-yl-sulphonamido anilines (2a-l) with chloroacetyl chloride in presence of triethyl amine. The physical and spectral data of synthesised compounds are determined. The synthesised compounds have been screened for their in vitro antimicrobial activity against various strains of bacteria and fungi.

KEYWORDS:

Azetidinone derivative; Antimicrobial activity

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Hirapara K. V, Joshi A. M, Patel S. P, Parekh H. H. Synthesis of 2-Azetidinones as Potential Antimicrobial Agents. Orient J Chem 2003;19(2).

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Hirapara K. V, Joshi A. M, Patel S. P, Parekh H. H. Synthesis of 2-Azetidinones as Potential Antimicrobial Agents. Orient J Chem 2003;19(2). Available from: http://www.orientjchem.org/?p=17770"

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