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Synthesis and Antimicrobial Activity of Pyrazine-2-Carboxylic Acid With Various Sulfonamide Derivatives

Volume 19, Number 2

N. B. Patel* and N. N. Patel

Department of Chemistry, South Gujarat University, Surat- 395 007 (India)

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ABSTRACT:

2-{N4-[N1-(Substituted aryl) p-amino benzene sulfonamido] carbonyl} pyrazine (IIIa-k) and 2-{[N-(p-substituted benzene) sulfonamido] carbonyl} pyrazine (IVI-0) have been carried out by the condensation of pyrazine -2-carbonyl chloride (II) which in turn were prepared from various sulfonamides and pyrazine -2- carboxylic acid (I). The structures of new compounds have established on the basis of elemental analysis, IR and 1H-NMR spectral data. The synthesized compounds have been evaluated for their antibacterial and antifungal activity.

KEYWORDS:

Study of sulphonamide derivatives

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Patel N. B, Patel N. N. Synthesis and Antimicrobial Activity of Pyrazine-2-Carboxylic Acid With Various Sulfonamide Derivatives. Orient J Chem 2003;19(2).

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Patel N. B, Patel N. N. Synthesis and Antimicrobial Activity of Pyrazine-2-Carboxylic Acid With Various Sulfonamide Derivatives. Orient J Chem 2003;19(2). Available from: http://www.orientjchem.org/?p=17803"

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