Determination of Dimetridazole by Visible Spectrophotometry
C. S. N. Sarma, C. Kamala Sastri and C. S. P. Sastry*
Department of Physical, Nuclear and Chemical Oceanography School of Chemistry, Andhra University, Visakhapatnam - 530 003 (India)
Four simple, sensitive and reproducible visible spectrophotometric methods (A-D) for the determination of Dimetridazole (DMZ) in bulk samples and pharmaceutical formulations are described. They are based on the formation of coloured species by treating reduced DMZ (RDMZ) with p-N-methylaminophenol sulphate (metol) following oxidation with potassium dichromate (Cr(VI)) (Method A) or condensation products with aromatic aldehydes namely, 4-dimethyl amino benzaldehyde (PDAB) under acidic conditions (Method B); molecular complex formation with sodium nitropursside (SNP) in the presence of hydroxylamine hydrochloride (HA) (Method C) or DMZ with p-aminophenol (PAP)-molecular oxygen (O2) (Method D). Regression analysis of Beer's law plots showed good concentration range 1.6-20.00 μg/ml, 2-25 μg/ml and 2.5-25 μg/ml and 3.5-40 μg/ml for methods A, B, C and D respectively. The applicability of the methods were examined by analysing dimetridazole premix.
KEYWORDS:Visible spectrophotometry; dimetridazole; regression analysis
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Copy the following to cite this URL: Sarma C. S. N, Sastri C. K, Sastry C. S. P, Determination of Dimetridazole by Visible Spectrophotometry. Orient J Chem 2002;18(1). Available from: http://www.orientjchem.org/?p=16987 |
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