ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Determination of Dimetridazole by Visible Spectrophotometry

C. S. N. Sarma, C. Kamala Sastri and C. S. P. Sastry*

Department of Physical, Nuclear and Chemical Oceanography School of Chemistry, Andhra University, Visakhapatnam - 530 003 (India)

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ABSTRACT:

Four simple, sensitive and reproducible visible spectrophotometric methods (A-D) for the determination of Dimetridazole (DMZ) in bulk samples and pharmaceutical formulations are described. They are based on the formation of coloured species by treating reduced DMZ (RDMZ) with p-N-methylaminophenol sulphate (metol) following oxidation with potassium dichromate (Cr(VI)) (Method A) or condensation products with aromatic aldehydes namely, 4-dimethyl amino benzaldehyde (PDAB) under acidic conditions (Method B); molecular complex formation with sodium nitropursside (SNP) in the presence of hydroxylamine hydrochloride (HA) (Method C) or DMZ with p-aminophenol (PAP)-molecular oxygen (O2) (Method D). Regression analysis of Beer's law plots showed good concentration range 1.6-20.00 μg/ml, 2-25 μg/ml and 2.5-25 μg/ml and 3.5-40 μg/ml for methods A, B, C and D respectively. The applicability of the methods were examined by analysing dimetridazole premix.

KEYWORDS:

Visible spectrophotometry; dimetridazole; regression analysis

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Sarma C. S. N, Sastri C. K, Sastry C. S. P, Determination of Dimetridazole by Visible Spectrophotometry. Orient J Chem 2002;18(1).


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Sarma C. S. N, Sastri C. K, Sastry C. S. P, Determination of Dimetridazole by Visible Spectrophotometry. Orient J Chem 2002;18(1). Available from: http://www.orientjchem.org/?p=16987



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