ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis and Antimicrobial Activity of Some New N-(4-N or N,N-Disubstituted Amino Sulfonyl Phenyl)-3-Chloro-4-Phenyl Azetidine-2-Ones

H. S. Patel and V. K. Patel

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar - 388 120, Gujarat (India)

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ABSTRACT:

Various 4-benzylideneazanyl-N or N,N-disubstituted benzene sulfonamides (3a-j) have been prepared by condensation of 4-amino-N- or N,N-disubstuted benzene sulfonamide (2) with benzaldehydes. These on cyclocondensation reaction of (3a-j) with chloroacetylchloride afforded N-(4-N or N,N-disubstituted amino sulfonyl phenyl)-3-chloro-4-phenyl azetidine-2-ones (4a-j). Biological screening of the prepared compounds have been carried out on some strains of bacteria.

KEYWORDS:

N;N-disubstituted benzene sulfonamides; cyclocondensation; azetidine

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Patel H. S, Patel V. K. Synthesis and Antimicrobial Activity of Some New N-(4-N or N,N-Disubstituted Amino Sulfonyl Phenyl)-3-Chloro-4-Phenyl Azetidine-2-Ones. Orient J Chem 2001;17(3).


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Patel H. S, Patel V. K. Synthesis and Antimicrobial Activity of Some New N-(4-N or N,N-Disubstituted Amino Sulfonyl Phenyl)-3-Chloro-4-Phenyl Azetidine-2-Ones. Orient J Chem 2001;17(3). Available from: http://www.orientjchem.org/?p=16940



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