ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of Some New 2,4-(Substituted Diaryl)-2,3-Dihydro, 8-Methoxy 1,5-Benzothiazepines as Antibacterial Agents

S. V. More1, S. A. Siddiqui1, Aasif Ali2, R. F. Siddiqui1, S. R. Bhusare2,

1Organic Chemistry Synthesis Laboratory, Dnyanopasak College, Parbhani – 431 401 (India) 2P.G. Department of Chemistry, Yeshwant College, Nanded-431 601 (India)  

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ABSTRACT:

The title compounds 3a-e have been synthesized from the corresponding 1-(2’-hydroxy-3’,5’-diiodo phenyl)-3-(substituted phenyl)-2-propen-1-ones (2) by condensation with 5-methoxy 2-amino thiophenol (1) in ethanol containing a few drops of piperidine followed by cyclisation in the presence of acetic acid. Some of the representative members have been screened for their antibacterial activity against Escherischia coli, Staphylococcus aureus and Proteus vulgaris.

KEYWORDS:

Benzothiazepines; antibacterial agents

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More S. V, Siddiqui S. A, Ali A, Siddiqui R. F, Bhusare S. R. Synthesis of Some New 2,4-(Substituted Diaryl)-2,3-Dihydro, 8-Methoxy 1,5-Benzothiazepines as Antibacterial Agents. Orient J Chem 2001;17(2).


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More S. V, Siddiqui S. A, Ali A, Siddiqui R. F, Bhusare S. R. Synthesis of Some New 2,4-(Substituted Diaryl)-2,3-Dihydro, 8-Methoxy 1,5-Benzothiazepines as Antibacterial Agents. Orient J Chem 2001;17(2). Available from: http://www.orientjchem.org/?p=16175



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