Synthesis and Biological Activity of 2-Azetidinone Bearing Benzothiazole Moiely

K. G. Ojha*, Neera Jaisinghani, Rashmi Upadhyay and Amar Singh Chittoria.

Department of Applied Chemistry, M.D.S. University, Ajmer – 305009 (India)

ABSTRACT:

Benzothiazolyl derivatives of 2- Azetidinones (III) were synthesized by the condensation of p-methoxybenzaldehyde with variously substituted 2-aminobenzothiazoles (I). The condensed products (II) were treated with acetyl chloride in presence of triethylamine in dioxane to get title compounds (III). These compounds were screened for the antibacterial activities against E.coli, S.aureus, P.mirabilis, Pseudomonas and Klebsiella spp.

KEYWORDS:

2-Azetidinone; Benzothiazole moiety; Antibacterial activity

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Copy the following to cite this article: Ojha. K. G, Jaisinghani. N, Upadhyay. R, Chittoria. A. S. Synthesis and Biological Activity of 2-Azetidinone Bearing Benzothiazole Moiely. Orient J Chem 2001;17(1).

Copy the following to cite this URL: Ojha. K. G, Jaisinghani. N, Upadhyay. R, Chittoria. A. S. Synthesis and Biological Activity of 2-Azetidinone Bearing Benzothiazole Moiely. Orient J Chem 2001;17(1). Available from: http://www.orientjchem.org/?p=15717