Dehydrogenation of 1-H-3-(2”-Hydroxy-3”-Substituted-5”-Chlorophenyl) 5-(2’-Furyl)-2-Pyrazolines and Their Derivatives With Antimicrobial Activities  

S. S. Thakare¹, A. G. Doshi² and S. D. Patil³

¹Department of Chemistry, Mahatma Fule Mahavidyalaya, Warud 444906 (India) ²Department of Chemistry, Vidya Bharti Mahavidyalaya, Amravati 444 602 (India) ³Department of Microbiology, Shri Shivaji Science College, Amravati 444 603 (India)

Pyrazolines was suspended in DMSO and a crystal of iodine added to it. The mixture was refluxed for one hour, cooled, diluted with water. The solid obtained was filtered, washed with 20% aqueous sodium thiosulphate and crystallised from ethanol to get pyrazole. The same reaction was carried out in DMSO-I2-H2SO4 system affords 3-(2”-hydroxy-3”-substituted-5”-chlorophenyl)-5-(2’-furyl)-pyrazole. Pyrazoles were tested for antimicrobial activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis and Bacillus megatherium. All compounds were found effective against both Gram positive and Gram negative bacteria in the MIC range of <25-200 μg/ml.

Dehydrogenation; antimicrobial activities