Synthesis of Some Newer Potent Antiinflammatory Substituted Phenothiazines
Ekta Bansal and Ashok Kumar
Medicinal Chemistry Laboratory. Department of Pharmacology, L.L.R.M. Medical College, Meerut - 250 004, India.
Article Received on : February 25,1999
Article Accepted on :
Twenty new phenothiazine derivatives were synthesized and screened against carrageenin induced oedema in albino rats. Almost all the compounds have shown promising anti-inflammatory activity, compound 4e' i.e. 10-[2-(3'-chloro-2'-oxo-4,-o-methoxypheny|-1,-azetidinyl)-4-oxazolyl] phenothiazine was found to be most potent The most potent compound was evaluated for its antiinflammatory potency, ulcerogenic lability and scute toxicity. It was found more potent than the standard drug, phenylbutazone.
KEYWORDS:phenothiazine; carrageenin; antiinflammatory potency; ulcerogenic
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| Copy the following to cite this article: Bansal E, Kumar A. Synthesis of Some Newer Potent Antiinflammatory Substituted Phenothiazines. Orient J Chem 1999;15(3). |
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