Synthesis of Sulfoxide Derivatives of Antibacterial Interest

Nabaweya Sharaf El-Din

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta Egypt.

ABSTRACT:

A series of heterocyclic sulfoxide derivatives (l-X) were prepared by cyclization of ethyl-p-methylphenyl sulfonyl acetpacetate or diethyl-p-methyl phenylsulfonyl malonate with hydrazine, phenylhydrazine, urea or o-phenylenediamine. The prepared compounds were found to be active against E. coli.

KEYWORDS:

Ethylphenyl sulfonyl acetoacetate; diethyl phenylsulfonyl malonate; pyrazole; pyrimidine; diazepine; antibacterial activity

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Copy the following to cite this article: El-Din N. S. Synthesis of Sulfoxide Derivatives of Antibacterial Interest. Orient J Chem 1999;15(1).

Copy the following to cite this URL: El-Din N. S. Synthesis of Sulfoxide Derivatives of Antibacterial Interest. Orient J Chem 1999;15(1). Available from: http://www.orientjchem.org/?p=36803