Polyphosphoric Acid Catalyzed Indolization of 4-Piperidone Phenylhydrazones

K. Kaniappan

Department of Chemistry, Sri Ramakrishna Engineering College, Coimbatore 641 022, Tamil Nadu India.

ABSTRACT:

A convenient synthesis of 1,3-diphenyl 1,2,3,4-tetrahydro-γ-carboline in quite encouraging yield through the Fischer-type indolization of phenylhydrazones (either preformed or formed in situ) of 2.6-diphenyl-4-piperidone in the presence of polyphosphoric acid is described. This involves a new synthetic strategy of 4-substituted 1.3-diphenyl-1,2,3,4-tetrahydro--γ-carbolines 3a-d. These compounds have been characterised through their IR and 1H NMR spectral analysis.

KEYWORDS:

Phenylhydrazones; Diphenyl; Tetrahydro Carbolines

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Copy the following to cite this article: Kaniappan K. Polyphosphoric Acid Catalyzed Indolization of 4-Piperidone Phenylhydrazones. Orient J Chem 1998;14(1).

Copy the following to cite this URL: Kaniappan K. Polyphosphoric Acid Catalyzed Indolization of 4-Piperidone Phenylhydrazones. Orient J Chem 1998;14(1). Available from: http://www.orientjchem.org/?p=21639