ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of 3,4,5-Trisubstituted Pyrazounes and their Antimicrobial Study

R. M. Kedar, N. N. Vidhale, M. M. Chincholkar

Government Vidarbha Mahavidyalaya, Amravati - 444 604 India.

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ABSTRACT:

Five 3-aoyl flavanones (la-e) were prepared by reacting diketones with aldehydes in ethanol in presence of pipendine. Each of these flavanones was reacted with semicarbazide hydrochloride and hydrazine hydrate in ethanol in presence of little piperidine to afford the formation of 1 -carboxamido-3,5-diaryl-4-aroyl pyrazoline and 3,5-diaryl-4-aroyl pyrazoline respectively. Further, these compounds were subjected to antimicrobial tests against the test organisms. Escherichia coli, Staphylococcus aureus, Proteus vulgaris, Klebsiella pneumoniae, Salmonella typhii, Shigella dysentry and Proteus mirabilis. Their MIC values were determined. Pyrazolines containing dim ethy lam ino group as a substituent have been found to possess higher antimicrobial activity.

KEYWORDS:

5-Trisubstituted; Pyrazounes; Antimicrobial; Antimicrobial; pyrazoline

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Kedar R. M, Vidhale N. N, Chincholkar M. M. Synthesis of 3,4,5-Trisubstituted Pyrazounes and their Antimicrobial Study. Orient J Chem 1997;13(3).


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Kedar R. M, Vidhale N. N, Chincholkar M. M. Synthesis of 3,4,5-Trisubstituted Pyrazounes and their Antimicrobial Study. Orient J Chem 1997;13(3). Available from:http://www.orientjchem.org/?p=37560



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