ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis and Biological Evaluation of Oxime Carbamates

S.K. Raza, A. Khullar and D. K. Jaiswal

Defence Research and Development Establishment, Gwalior-472 002 India

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ABSTRACT:

A series of carbamates derived from pyridine aldoximes and thiohydroximic thioesters have been prepared by their reaction with isocyanates. The quaternised salts of pyridine aldoxime carbamates have also been synthesised. The compounds synthesised were evaluated for their efficacy as acetylcholinesterase inhibitors. Most of these were found to be good inhibitors, their 150 values ranged between 10-6 - 10-9 M.

KEYWORDS:

Biological; Oxime; Carbamates; Synthesised

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Raza S. K, Khullar A, Jaiswal D. K. Synthesis and Biological Evaluation of Oxime Carbamates. Orient J Chem 1994;10(3).


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Raza S. K, Khullar A, Jaiswal D. K. Synthesis and Biological Evaluation of Oxime Carbamates. Orient J Chem 1994;10(3). Available from:http://www.orientjchem.org/?p=38299



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