ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

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Synthesis of Some 5-nitro Heteroaryl-phenylpropenones with Antituberculosis

Songuigama Coulibaly1, Jean-Paul D.U. N'Guessan1, Jean-Fabrice K. Koffi 1,2, Soro T. GrĂ¢ce1 and Mahama Ouattara1*


Abstract:

The treatment of tuberculosis (TB) faces several challenges, such as the emergence of drug-resistant TB, long treatment duration, management of latent TB, and toxic adverse effects leading to non-compliance with treatment. To address this, WHO encourages the search for new molecules that are more effective and better tolerated. In this context, hybrid molecules of the 5-nitro heteroaryl-phenylpropenone type have been designed as new anti-tuberculosis drugs. These compounds were developed by molecular hybridization, combining a pentagonal 5-nitro heteroaryl with a phenylpropenone functional chain. Four derivatives were synthesized by condensation of a 5-nitro heteroaryl carbaldehyde derivative and a selected ketone, with yields ranging from 20 to 74%. Their structure was confirmed by spectroscopic methods. These new compounds must now be evaluated on different strains of Mycobacterium tuberculosis to confirm their anti-tuberculosis potential.

Keywords:

Anti-tuberculous; Chalcones; Heteroaryl pentagonals; 5-nitro heteroaryl-phenylpropenone

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