Abstract

Pooja Bedi¹, Rajbir Kaur¹ , Reshmi Bose², Bholanath Pakhira³, Manas Roy⁴ and Tanay Pramanik^2*

DOI : http://dx.doi.org/10.13005/ojc/400502

Bis(indolyl)methane’s (BIMs) are highly versatile heterocyclic frameworks that have gained recognition for their wide range of applications in the therapeutic and pharmaceutical sectors, and play an essential role in the drug discovery system. Though several methodological approaches have been adopted for the synthesis of BIMs, these methods have limitations in terms of using hazardous solvents, transition-metal catalysts, and ultimately generating substantial waste. This review emphasized the green synthesis of BIMs, using the one-pot multicomponent condensation (OPMC) method, which offers BIM synthesis via renewable catalysts, green solvents, or a catalyst-free approach. The OPMC method offers numerous advantages, such as reduced time, labour, cost, and waste products. Multicomponent condensation reactions are very effective in synthesizing highly functionalized organic molecules in one step from readily available starting materials. Despite advancements, challenges persist in ensuring the catalyst's stability for optimal yields and compatibility with various substrates. In the present context, only the OPMC synthesis of bis(indolyl) methane was articulated, which provides valuable insights for researchers seeking sustainable pathways for BIM synthesis.

Bis(indolyl)methane; Green solvents; Green approaches; One-pot multicomponent condensation

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