Synthesis and Quaternization of 5-Amino-1-Aryl-Imidazol- 4-Carboxamides and Their Related Imidazo-Pyrahnes

Khairy A. M. El-Bayouki, M. Hammad, S. A. Osman And W. M. Basyouni

National Research Centre, Dokki, Cairo, Egypt.

ABSTRACT:

Synthesis of some new 5-amino-1-(aryl)-imidazole-4-carbox-amides 3 via two routes is described. Reactions of 3 with ethyl bromoacetate and phenacyl bromide afforded the quatetnary-pyrazine-4-ium 4 and - phenacy-imidazolium 7 bromides respectively. The aryl-amino-imidazo-pyrazines 6 and 9 are obtained from the synthesized bromide, Structure of the products is confirmed by i.r.u.v. H1n.m.r and mass spectral determinations.

KEYWORDS:

5-Amino-1-Aryl-Imidazol- 4-Carboxamides; Related

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Copy the following to cite this article: El-Bayouki K. A. M, Hammad M, Osman S. A, Basyouni W. M. Studies on Amoebicidal Agents : II. Synthesis And Amoebicidal Activity of Toluene-2:4-Bis-Sulfon-N-Anilides. Orient J Chem 1986;2(1).

Copy the following to cite this URL: El-Bayouki K. A. M, Hammad M, Osman S. A, Basyouni W. M. Studies on Amoebicidal Agents : II. Synthesis And Amoebicidal Activity of Toluene-2:4-Bis-Sulfon-N-Anilides. Orient J Chem 1986;2(1). Available from: http://www.orientjchem.org/?p=42352