Synthesis and Biological Activity of Certain Substituted Thienopy Rimidones

S. H. El-Zanfally, M. M. El-Enany,* S. M. Roshdy* And A. A- Moneer

Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo Egypt.

ABSTRACT:

A series of 2-styryl-3-aryl-4-oxo-5,6-tetramethylenethieno [ 2,3-d ] pyrimidines have been synthesized (V1-20). Condensation of 2-methyl-4-oxo-5,6-tetramethylenthieno [ 3,1 ] oxazine with certain heteroaromatic amines afforded the corresponding thienopyrimidone derivatiyes (VI1,2). Some compounds have been pharmacologically screened for their hypnotic activity.

KEYWORDS:

Biologicall; Substituted; Thienopy; Rimidones

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Copy the following to cite this article: El-Zanfally S. H, El-Enany M. M, Roshdy S. M, Moneer A. A. Synthesis and Biological Activity of Certain Substituted Thienopy Rimidones. Orient J Chem 1989;5(3).

Copy the following to cite this URL: El-Zanfally S. H, El-Enany M. M, Roshdy S. M, Moneer A. A. Synthesis and Biological Activity of Certain Substituted Thienopy Rimidones. Orient J Chem 1989;5(3). Available from: http://www.orientjchem.org/?p=41456