Developement and Validation of Dissolution Test for Tamsulosin Hydrochloride Pellets

Mandava V. Basaveswara Rao*, B. C. K Reddy, T. Srinivas Rao and Anjali Jha

Department of Chemistry, G.I.T.A.M University, Visakhapatnam - 530 045 (India).

ABSTRACT:

A simple and rapid dissolution test for Tamsulosin Hydrochloride pellets 0.2% has been developed and validated. Based on the stability and basic nature of the drug, dissolution experiments were conducted at pH 1.2 and pH 7.2 with paddle stirring at 100 rotations per minute (rpm). Dissolution was found to be less than 40% over a period of 2 hours, between 55 and 75% till 3hours and more than 85% 5hours. The quantitative recovery of the drug from semi formulations was established indicating non interference of excipients. The dissolution profile for pellets was considered satisfactory and could be applied for quality control of Tamsulosin Hydrochloride Pellets 0.2% since there is no such report available.

KEYWORDS:

Dissolution test; tamsulosin hydrochloride pellets

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Copy the following to cite this article: Rao M. V. B, Reddy B. C. K, Rao T. S, Jha A. Developement and Validation of Dissolution Test for Tamsulosin Hydrochloride Pellets. Orient J Chem 2008;24(3).

Copy the following to cite this URL: Rao M. V. B, Reddy B. C. K, Rao T. S, Jha A. Developement and Validation of Dissolution Test for Tamsulosin Hydrochloride Pellets. Orient J Chem 2008;24(3). Available from: http://www.orientjchem.org/?p=25088