Development of An Efficient and Scalable Process for Rocuronium Bromide: A Neuromuscular Blocking Agent

Neti Srinivasan¹-², Vijayavitthal T. Mathad¹, Vurimindi Himabindu²

¹Dr.Reddy’s Laboratories Ltd., Integrated Product Development, Innovation Plaza, Bachupalli, Qutubullapur, R R District - 500 072 (India).

²Centre for Environmental Sciences, JNT University, Kukatpally, Hyderabad - 500 072 (India).

ABSTRACT:

An efficient, scalable and high yielding process is developed for a neuromuscular blocking agent Rocuronium bromide 1 by studying various process parameters. The process involves simple work up and obviates column chromatography purification and usage of commercially unacceptable solvents.

KEYWORDS:

Rocuronium Bromide; neuro muscular blocking agent; diepoxide; acetylation; allylation

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Copy the following to cite this article: Srinivasan N, Mathad V. T, Himabindu V. Development of An Efficient and Scalable Process for Rocuronium Bromide: A Neuromuscular Blocking Agent. Orient J Chem 2008;24(3).

Copy the following to cite this URL: Srinivasan N, Mathad V. T, Himabindu V. Development of An Efficient and Scalable Process for Rocuronium Bromide: A Neuromuscular Blocking Agent. Orient J Chem 2008;24(3). Available from: http://www.orientjchem.org/?p=25027