Synthesis, Characterization and Biological Activity of Cu(II) and Ni(II) Complexes of 3-Hydroxy- 4- (Pyridine-2-yl-Methylene Amino) Benzoic Acid

K. Jamuna, D. Harikishore Kumar Reddy,B. Naresh Kumar, D.K.Venakata Ramana and K. Seshaiah*

Department of Chemsitry, Sri Venkateswara University, Tirupati - 517 502 (India).

ABSTRACT:

The synthesis, characterization and biological activity of Cu(II) and Ni(II) complexes derived from tridentate Schiff base ligand 3-hydroxy-4-(pyridine-2-yl methylene amino) benzoic acid (HL) was obtained by the condensation of 2-Pyridine carboxaldehyde with 4-amino 3-hydroxy benzoic acid has been described. The complexes were characterized based on elemental analyses, molar conductivity measurements, FT-IR, UV-vis and thermogravimetric analysis. The Schiff base acts as tridentate mono basic donor, coordinating through the azomethine nitrogen, phenolic OH and pyridynyl nitrogen. The ligand and their metal complexes were screened against bacteria and fungi. Data obtained showed that metal complexes have shown higher biological activity Schiff base ligand.

KEYWORDS:

Schiff base; Copper; Nickel; Transition metal complexes; Biological activity

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Copy the following to cite this article: Jamuna K, Reddy D. H. K, Kumar B. N, Ramana D. K. V, Seshaiah K. Synthesis, Characterization and Biological Activity of Cu(II) and Ni(II) Complexes of 3-Hydroxy- 4- (Pyridine-2-yl-Methylene Amino) Benzoic Acid. Orient J Chem 2011;27(3).

Copy the following to cite this URL: Jamuna K, Reddy D. H. K, Kumar B. N, Ramana D. K. V, Seshaiah K. Synthesis, Characterization and Biological Activity of Cu(II) and Ni(II) Complexes of 3-Hydroxy- 4- (Pyridine-2-yl-Methylene Amino) Benzoic Acid. Orient J Chem 2011;27(3). Available from: http://www.orientjchem.org/?p=24575