Synthesis of 4-[(2' Substituited) Phenyl]-1', 2'-Di Substituted Anilino Ethyl Coumarin as Anti Bacterial and Antifungal Agents

Vikas Choudhary², R. C. Agarwal², Kanu Pirya Vishnoy¹ and Ashok Ku

¹Department of Pharmacology, LLRM Medical College, Meerut - 250 004 India.

²Department of Chemistry Hindu College Moradabad India.

ABSTRACT:

4 methyl coumarin (1) was prepared by the reaction of phenol and ethylacetoacetate in the presence of conc. H2SO4, (1) on react with substituted benzoldehyde in presence of 2% NaOH to gave 4[substituted styryl] coumarin (2a - 2d), further on bromination it converted into 4[2' substituted phenyl -1' 2' di bromo-ethyl] coumarin [3a - 3d], The solution of the compounds (3a - 3d) in methanol were refluxed with substituted aniline to form 4[2' (substituted phenyl) -1', 2' disubstituted anilinoethyl] coumarin (4a - 4t). Structure of all these newly synthesized compounds are confirmed by their analytical and spectral data. The compounds were evaluated for their antibacterial and antifungal activities. Most active compounds 4n and 4O were found to posses potent antibacterial and antifungal activities against Staph. aureus 209p and Candida albicans ATCC 10231 respectively.

KEYWORDS:

4 methyl coumarin; antibacterial and antifungal agents

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Copy the following to cite this article: Choudhary V, Agarwal R. C, Vishnoy K. P, Ashok K. Synthesis of 4-[(2' Substituited) Phenyl]-1', 2'-Di Substituted Anilino Ethyl Coumarin as Anti Bacterial and Antifungal Agents. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Choudhary V, Agarwal R. C, Vishnoy K. P, Ashok K. Synthesis of 4-[(2' Substituited) Phenyl]-1', 2'-Di Substituted Anilino Ethyl Coumarin as Anti Bacterial and Antifungal Agents. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=24468