One Pot Synthesis of 3, 4-Dihydropyrimidin - 2(1H) - Ones Catalyzed by Aluminium Sulphate: an Improved Procedure for the Biginelli Reaction

B. J. Khairnar, R. J. Kapade, K. M. Borse and B. R. Chaudhari*

Department of Chemistry, JET’s Zulal Bhilajirao Patil College, Dhule- 424 002 (India).

ABSTRACT:

A simple effective synthesis of 3, 4-dihydropyrimidin-2(1H)-one/thione derivatives using Aluminium sulphate (Al2 (sO4)3.18H2O) catalyst from aromatic aldehydes, 1, 3-dicarbonyl compounds & (thio)urea in glacial acetic acid is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yield and short reaction time.

KEYWORDS:

Biginelli reaction; 3; 4-dihydropyrimidin-2(1H)-ones; Aluminium sulphate; Condensation reaction; multicomponent reaction

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Copy the following to cite this article: Khairnar B. J, Kapade R. J, Borse K. M, Chaudhari B. R. One Pot Synthesis of 3, 4-Dihydropyrimidin - 2(1H) - Ones Catalyzed by Aluminium Sulphate: an Improved Procedure for the Biginelli Reaction. Orient J Chem 2010;26(2).

Copy the following to cite this URL: Khairnar B. J, Kapade R. J, Borse K. M, Chaudhari B. R. One Pot Synthesis of 3, 4-Dihydropyrimidin - 2(1H) - Ones Catalyzed by Aluminium Sulphate: an Improved Procedure for the Biginelli Reaction. Orient J Chem 2010;26(2). Available from: http://www.orientjchem.org/?p=24126