ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of 3-(1-Phenyl-Vinyl)-1, 2, 5-Trioxa-Spiro Undecane and its Derivatives

Volume 24, Number 2

Lalit Kumar*1, Pardeep Kumar3, and Niranjan kaushik2

1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka India.

2College of Pharmacy, IFTM, Moradabad, India.

3Department of Pharmaceutical Analysis, PES College of Pharmacy, Bangalore, Karnataka India.

   

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ABSTRACT:

3-(1-Phenyl-vinyl)-1, 2, 5-trioxa-spiro undecane is synthetic derivative of Artemisinin. Artemisinin is a well known antimalarial drug from leaves of Artemisia annua find in china. Five different derivatives of 3-(1-Phenyl-vinyl)-1, 2, 5-trioxa-spiro undecane were synthesized using well standardized method. These compounds were purified by simple column chromatography and successfully analysed using H1NMR, IR and FAB-MS techniques.

KEYWORDS:

1, 2, 4-trioxane; Artemisinin; NMR; IR; FAB-MS

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Kumar L, Kumar P, kaushik N. Synthesis of 3-(1-Phenyl-Vinyl)-1, 2, 5-Trioxa-Spiro Undecane and its Derivatives. Orient J Chem 2008;24(2).

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Kumar L, Kumar P, kaushik N. Synthesis of 3-(1-Phenyl-Vinyl)-1, 2, 5-Trioxa-Spiro Undecane and its Derivatives. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23922

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