Synthesis of Some Novel Flavonol Derivatives and its Microbial Activity

Satish B. Jadhav*, Karuna R. Bagul,Pradnya R. Bagul and Kishor V. Gaikwad

P. G. Department of Chemistry, Milind College of Science Aurangabad - 431 001 India.

ABSTRACT:

A series of flavonol derivatives were synthesized according to Algar-Flym-Oyamada reactions and chalcone were was synthesis according to the Claisen-Schmidt reactions. Chalcones were prepared by condensing equimolar of o-hydroxy acetophenones with 6-methoxynapthadehyde in alcoholic alkaline medium at room temperature. The resultant chalcones were immediately reacted with H2O2 in the presence of a mixture of aqeous alcoholic alkali to obtained corresponding flavonol. All the syntesized flavonol were characterized by means of their, IR, ¹HNMR, Mass spectral data, elemental analysis and their physical properties. All flavonol were tested for their anfifungal and antibacterial activity. All the sysntesized flavonol exhibited moderate to good antimicrobial activity.

KEYWORDS:

Synthesis of chalcones; flavonol; Antifungal and Antibacterial activity

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Copy the following to cite this article: Jadhav S. B, Bagul K. R, Bagul P. R, Gaikwad K. V. Synthesis of Some Novel Flavonol Derivatives and its Microbial Activity. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Jadhav S. B, Bagul K. R, Bagul P. R, Gaikwad K. V. Synthesis of Some Novel Flavonol Derivatives and its Microbial Activity. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23918