Synthesis and Biological Studies of 1, 2, 3, 4-Tetrahydro Pyrimidine Derivatives

Parthiv K. Chaudhari, Ajay Pandey and V. H. Shah

   

Department of Chemistry, K. S. K. V. Kachchh University, Bhuj-Kachchh India.

ABSTRACT:

It has been found that several DHPM derivatives possess biological activity, which has led to their use as antiviral, antibiotic, anticarcinogenic, antihypertensive, antitubericular, anti mycobacterial or anticancer activity. Further more, DHPM s are chiral compounds and it has been discovered that the configuration at the steriogenic carbon C4 determines their biological properties. DHPMs Derivatives are synthesized via a multicomponent reaction of aldehyde derivative, urea or thiourea and 1,3-dicarbonyl compounds using Biginelli Reaction and microwave irradiation catalyzed by HCl. 1H NMR, IR, mass spectra and CHN analysis data established identification of the compounds are evaluated for their antiviral, antibiotic, anticarcinogenic, antihypertensive, antitubericular ,anti mycobacterial or anticancer activity.

KEYWORDS:

Dihydropyrimidines; Antitubercular activity; Antimycobacterial activity

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Copy the following to cite this article: Chaudhari P. K, Pandey A, Shah V. H. Synthesis and Biological Studies of 1, 2, 3, 4-Tetrahydro Pyrimidine Derivatives. Orient J Chem 2010;26(4).

Copy the following to cite this URL: Chaudhari P. K, Pandey A, Shah V. H. Synthesis and Biological Studies of 1, 2, 3, 4-Tetrahydro Pyrimidine Derivatives. Orient J Chem 2010;26(4). Available from: http://www.orientjchem.org/?p=23861