Three Component Solvent-Free Synthesis and Fungicidal Activity of Substituted Pyrimido [4,5-D] Pyrimidine-2-(1h)-One
Sandeep V. Shinde1*, Wamanrao N. Jadhav1 And Nandkisohr N. Karade2
1Post Graduate Research Centre, Dnyanopasak College, Parbhani, 431 401 (India).
2School of Chemical Sciences, S.R.T.M. University, Nanded, 431 606 (India).
A novel three component condensation of aromatic aldehyde, urea or thiourea and barbituric acid or N,N-1,3-dimethylbarbituric acid was carried out using L-proline as an organo-catalyst under solvent-free microwave conditions. The resulting product, pyrimido [4,5-d] pyrimidine-2-(1H)-one was checked for the fungicide activity.
KEYWORDS:Fungicidal acitivity; aromatic aldehyde
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| Copy the following to cite this article: Shinde S. V, Jadhav W. N, Karade N. N. Three Component Solvent-Free Synthesis and Fungicidal Activity of Substituted Pyrimido [4,5-D] Pyrimidine-2-(1h)-One. Orient J Chem 2010;26(1). |
| Copy the following to cite this URL: Shinde S. V, Jadhav W. N, Karade N. N. Three Component Solvent-Free Synthesis and Fungicidal Activity of Substituted Pyrimido [4,5-D] Pyrimidine-2-(1h)-One. Orient J Chem 2010;26(1). Available from: http://www.orientjchem.org/?p=23812 |
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